Treatment with Mestinon®

for myasthenia gravis

Product Information

WHAT DISEASE DOES MESTINON® TREAT?

MESTINON has been useful in the treatment of myasthenia gravis for decades. MESTINON can be used as first line treatment of myasthenia gravis.

WHAT IS MESTINON (pyridostigmine bromide,USP) AND HOW DOES IT WORK?

Myasthenia gravis is an autoimmune disease that attacks acetylcholine receptors. As a result, there is less acetylcholine signaling from nerve to muscle, leading to symptoms of muscle weakness. MESTINON prevents the breakdown of acetylcholine (pronounced "a cee til coline"), thereby allowing more acetylcholine to accumulate. Acetylcholine is the chemical that sends nerve impulses to the muscle. With more acetylcholine, there is more control of voluntary functions (such as eye movements, swallowing, and breathing) and limited strength. Individual results may vary.

WHAT IS THE RIGHT DOSAGE OF MESTINON FOR ME?

The amount of MESTINON that you take, as well as how many times a day you take it, can be different for each patient. Be sure to follow your doctor's instructions carefully. Do not change your dose unless you talk with your doctor, as too much can result in extreme muscle weakness and may lead to death.

THREE DOSAGE FORMS OF MESTINON

Conventional MESTINON Tablets each contain 60 mg pyridostigmine bromide.

MESTINON Syrup: One teaspoon of raspberry-flavored syrup contains 60 mg of pyridostigmine bromide. It is more easily swallowed, especially in the morning, by patients with swallowing difficulties.

MESTINON TIMESPAN® Tablets contain 180 mg pyridostigmine bromide. TIMESPAN Tablets are a slow-release dosage form.

INDICATION

Mestinon (pyridostigmine bromide) is useful in the treatment of myasthenia gravis.

IMPORTANT SAFETY INFORMATION

  • Do not use MESTINON if you have medical conditions known as mechanical intestinal obstruction or urinary obstruction. MESTINON should be used with caution if you have bronchial asthma.
  • If you experience increased muscle weakness, contact your doctor immediately as it could be a sign of a very serious condition.
  • Every patient has an individualized dose of MESTINON; follow your doctor’s instructions carefully. Tell your doctor about any side effect that you may experience.
  • The most common side effects of MESTINON are nausea, vomiting, diarrhea, abdominal cramps, increased movement of the organs of the gastrointestinal track such as the esophagus and the intestines, increased salivation, increased bronchial (lung) secretions, contraction of the pupil, and increased sweating. Other common side effects are muscle cramps, muscle twitches, and weakness. A skin rash may be seen in an occasional patient.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also contact Valeant Customer Service at 1-800-556-1937.

Click here for Prescribing Information for MESTINON

STORAGE OF MESTINON TABLETS AND TIMESPAN TABLETS

MESTINON Tablets and TIMESPAN Tablets are very hygroscopic (pronounced "hi gro ska pic"), which means they readily pick up and retain moisture. Moist MESTINON TIMESPAN Tablets may become mottled or discolored. This apparence change does not alter the effectiveness of the drug.

Store MESTINON in a dry place. Do not store MESTINON Tablets or TIMESPAN Tablets in bathrooms or kitchens where there is a higher incidence of moisture in the air.

MESTINON Tablets are packaged in a bottle of 100 or 500 tablets. MESTINON TIMESPAN is packaged in a bottle of 30 tablets. Do not remove the desiccant(s) (a small canister containing a drying agent) from any MESTINON prescription bottle.